Cancitis – an abbreviation of Cancer and the Latin word itis for inflammation - is part of the National Center for Mathematical Modeling - Human Health and Disease (COMMAND) at RUC. The Center for Mathematical Modeling - Health and Disease collaborates with the PandemiX Center, Center for Big Data and Center for Sundhedsfremmeforskning at RUC.
Nationally we have a well established collaboration with Hospitals in Region Copenhagen and in particular Dept. of Hematology, Region Zealand, Roskilde. The collaboration includes co-financed PhD students/postdocs focusing on educating and recruiting young researchers. We are member of the Danish Life Science Cluster “Center for (Early) Diagnosis and Treatment/Clinical Health Data Science” and Key member of the Greater Copenhagen CAG (Clinical Academic Group) initiative “ZIRI: The Zealand Inflammation Research Initiative. Chronic Inflammation, Vascular Diseases, and Cancer. Mutations in Blood Cells - a Common Link?”.
The Cancitis group and the Center for Mathematical Modeling - Health and Disease at RUC host a recent Lundbeck-Foundation’s Fellowship led by Prof. Thomas Stiehl. The Fellowship project on “Mathematical modeling of Acute Leukemia” (2021-2025) is a five-year and 10 Mill DKK grant in collaboration with Zealand University Hospital, Department of Hematology. The team members have successfully been investigating ways to work with Region Zealand and Region Copenhagen blood bank data and the Statens Serum Institute to create a brand new natural observatory for disease protection (antibodies, mutations, etc.) in Danish population age cohorts.
DOI: 10.1002/sdr.1670
Zamra Sajid, Morten Andersen and Johnny T. Ottesen
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DOI: 10.1016/j.jtbi.2021.110620
Rasmus Kristoffer Pedersen, Morten Andersen, Thomas Stiehl and Johnny T. Ottesen
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DOI: 10.3934/mbe.2020389
Katrine O. Bangsgaard, Morten Andersen, Vibe Skov, Lasse Kjær, Hans C. Hasselbalch and Johnny T. Ottesen
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DOI: 10.1016/j.mbs.2020.108372
Morten Andersen, Hans C. Hasselbalch, Lasse Kjær, Vibe Skov and Johnny T. Ottesen
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DOI: 10.1002/cam4.2741
Rasmus K. Pedersen, Morten Andersen, Trine A. Knudsen, Zamra Sajid, Johanne Gudmand-Hoeyer, Marc J. B. Dam, Vibe Skov, Lasse Kjær, Christina Ellervik, Thomas S. Larsen, Dennis Hansen, Niels Pallisgaard, Hans C. Hasselbalch and Johnny T. Ottesen
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DOI: 10.3934/mbe.2019418
Zamra Sajid, Morten Andersen and Johnny T. Ottesen
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DOI: 10.1016/j.jtbi.2019.01.001
Johnny T. Ottesen, Rasmus K. Pedersen, Zamra Sajid, Johanne Gudmand-Høyer, Katrine O. Bangsgaard, Vibe Skov, Lasse Kjær, Trine A. Knudsen, Niels Pallisgaard, Hans C. Hasselbalch, and Morten Andersen
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DOI: 10.1371/journal.pone.0183620
Morten Andersen, Zamra Sajid, Rasmus K. Pedersen, Johanne Gudmand-Hoeyer, Christina Ellervik, Vibe Skov, Lasse Kjær, Niels Pallisgaard, Torben A. Kruse, Mads Thomassen, Jesper Troelsen, Hans Carl Hasselbalch, Johnny T. Ottesen
Link to journal View PDF View supplementary materialRasmus Kristoffer Pedersen
SlidesSpeakers: Rasmus Kristoffer Pedersen (Roskilde University), Thomas Stiehl (Heidelberg University), Jesper Troelsen (Roskilde University) and Peter Ashcroft (ETH Zurich)
Morten Andersen
Zamra Sajid
Rasmus Kristoffer Pedersen
Johnny T. Ottesen
Morten Andersen
Zamra Sajid
Rasmus Kristoffer Pedersen
Cohort of patients treated with either Hydroxyurea or Interferon-alpha animated over time from baseline (time of diagnoses) to 36 month after. First axis show percent changes in JAK2 allele burden and second axis shows the hematopoietic Biomarker Index (HBI), a weighted average of distance to normalized blood cell levels. Full remission corresponds to be at the lower left corner of the diagram. To calculate the HBI we determine the distance from the normal level for each of the three biomarkers (leucocyte count, platelet count and LDH). If a measurement lies above the normal level we calculate the distance to the upper limit of the normal level and if the measurement lies below the normal level we calculate the distance to the lower limit of the normal level. If a measurement falls within the normal level it adds zero to the HBI. To give each biomarker comparable weight we weigh the distances by the upper limit for the normal level of each biomarker. An example of the HBI calculation: The numbers indicate how far from the normal level each measurement is. The measurements which fall inside the normal levels do not contribute to the HBI. Taking the final measurement as an example the thrombocyte contribution is 264/390 ≈ 0.68, the leucocyte contribution is 4.0/8.8 ≈ 0.45 and the LDH contribution is 123/230 ≈ 0.53 and thus the HBI in this case is approximately 0.68 + 0.45 + 0.53 = 1.66. If the three cell counts were all in the normal range the HBI would be 0.
Problem-statements and examples for use for danish high-school students working on either SRP or SOP assignments.
View moreDanish article about our collaboration with clinicians.
View moreDanish article about blood cancers and our work.
View moreCollection of various material, intended for use in danish high-school in collaboration with Roskilde University.
View moreVideo (In danish)
Danish radio feature about mathematical modelling and blood cancers.
View moreMalthe Frøkjær-Rubbås
Magnus Skjold Frederiksen, Uffe Bundesen, Karl Skovfoged Nordentoft, Kenny Haslund Andersen, Max Thrane Nielsen and Poul Thrane
Stine G. Fohrmann, Lukas Rasocha, Jūlija Tumanovska, Julien Hirsch and Kata M. Riegels
Ilayda Dilara Pusat, Emira Havkic and Kimmie Britoft
Bjørn Dan Orfang Nielsen, Frederik Vedel Gantzel, Karl Skovfoged Nordentoft, Kenny Haslund Andersen, Max Thrane Nielsen and Poul Thrane
Daniel Vestma Norén, Emely Overby, Kimmie Schäfferling Britoft, Mads Jens Køie Nielsen, Mette Michelle Unterborg Alempiew and Michelle Vigant Nielsen
Mathis Brette Mortensen, Natalia Stati, Irida Gkouzou and Magnus Skjold Frederiksen
Jeannie Bøg Rasmussen, Maria Nørr and Mehmet Temizsoy
Mikkel Zielinski Ajslev, Hasan M. M. Osman and Stefan Bisgaard
Our main work concerns the Cancitis Model, as introduced in our 2017 PLOS One paper. Below is a schematic overview of the compartments of the model.
The corresponding system of ordinary differential equations is given as:
$$ \begin{align} \frac{dx_0}{dt} &= (r_x \phi_x s- a_x - d_{x0}) x_0 - r_m s x_0 \\
\frac{dx_1}{dt} &= a_x A_x x_0 - d_{x1} x_1 \\ \frac{dy_0}{dt} &= (r_y \phi_y - a_y - d_{y0}) y_0 + r_m s x_0 \\
\frac{dy_1}{dt} &= a_y A_y y_0 - d_{y1} y_1 \\
\frac{da}{dt} &= d_{x0} x_0 + d_{y0} y_0 + d_{x1} x_1 + d_{y1} y_1 -e_a a s\\
\frac{ds}{dt} &= r_s a - e_s s + I
\end{align} $$
where \( \phi_x (x_0,y_0) = \frac{1}{1+c_{xx}x_0 + c_{xy}y_0} \) and \( \phi_y (x_0,y_0) = \frac{1}{1+c_{yx}x_0 + c_{yy}y_0} \)
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