Roskilde University Entrance

The Cancitis research group

About Us

We are a group of mathematicians from the Department of Science and Environment at Roskilde University, Denmark.


Our work deals with mathematical modelling of blood cancers, in particularly the myeloproliferative neoplasms (MPNs).


On this page you can read about our group, our work and our publications.

Our Team

Morten Andersen Associate Professor

RUC Research Profile.

Zamra Sajid Ph.D. student

RUC Research Profile.

Rasmus K. Pedersen Ph.D. student

RUC Research Profile.

Personal Website.

Marc John Bordier Dam Ph.D. student

RUC Research Profile.

Previous members

Johanne Gudmand-Høyer Ph.D. graduate, 2018

RUC Research Profile.

Published articles and other work

Mathematical Modelling as a Proof of Concept for MPNs as a Human Inflammation Model for Cancer Development

Published in PLoS One, 2017 12(8)

DOI: 10.1371/journal.pone.0183620

Morten Andersen, Zamra Sajid, Rasmus K. Pedersen, Johanne Gudmand-Hoeyer, Christina Ellervik, Vibe Skov, Lasse Kjær, Niels Pallisgaard, Torben A. Kruse, Mads Thomassen, Jesper Troelsen, Hans Carl Hasselbalch, Johnny T. Ottesen

View Article

Bridging blood cancers and inflammation: The reduced Cancitis model

Published in Journal of Theoretical Biology, 2019, Volume 465

DOI: 10.1016/j.jtbi.2019.01.001

More info and additional figures

Johnny T. Ottesen, Rasmus K. Pedersen, Zamra Sajid, Johanne Gudmand-Høyer, Katrine O. Bangsgaard, Vibe Skov, Lasse Kjær, Trine A. Knudsen, Niels Pallisgaard, Hans C. Hasselbalch, and Morten Andersen

View Article

Mathematical Analysis of the Cancitis model and the role of inflammation in blood cancer progression.

Published in Mathematical Biosciences and Engineering, 2019, 16(6)

DOI: 10.3934/mbe.2019418

Zamra Sajid, Morten Andersen and Johnny T. Ottesen

View Article

Other things

Presentations, posters and seminars.

Stem Cell Modelling Day

Seminar at Roskilde University - September 18th 2019

Speakers: Rasmus Kristoffer Pedersen (Roskilde University), Thomas Stiehl (Heidelberg University), Jesper Troelsen (Roskilde University) and Peter Ashcroft (ETH Zurich)

"Hematopoiesis or inflammation driven blood cancer? Insights from mathematical modelling"

Talk - SMB 2019, Montreal

Morten Andersen

"Modelling Myeloproliferative Neoplasms - Dynamics of myeloid cell lin for Ph-negative MPNs"

Poster - SMB 2019, Montreal

Zamra Sajid

"Modelling the Dynamics of Hematopoietic Stem Cells"

Poster - SMB 2019, Montreal

Rasmus Kristoffer Pedersen

"The Cancitis model: a couple leukemic-inflammatory response"

Talk - ECMTB 2018, Lisbon

Johnny T. Ottesen

"Mathematical modelling of blood cancer evolution"

Talk - ECMTB 2018, Lisbon

Morten Andersen

"Modelling the myeproliferative neoplasms (MPNs): Stability analysis & sensitivty analysis"

Poster - ECMTB 2018, Lisbon

Zamra Sajid

"Modelling of quiescent stem cells in relation to myeloproliferative neoplasms"

Poster - ECMTB 2018, Lisbon

Rasmus Kristoffer Pedersen

Outreach and dissemination

"Undervisningspakke - Matematisk modellering af cancer"

High-school teaching material (Only in danish)

Collection of various material, intended for use in danish high-school in collaboration with Roskilde University.

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Video (In danish)

"Så Vidt Vi Ved - P1"

Radio-interview (Only in danish)

Danish radio feature about mathematical modelling and blood cancers.

View more

Student projects

"Bag om Matematisk Modellering"

2018

Bjørn Dan Orfang Nielsen, Frederik Vedel Gantzel, Karl Skovfoged Nordentoft, Kenny Haslund Andersen, Max Thrane Nielsen and Poul Thrane

"Matematisk modellering af non-hodgkins lymfoma"

2018

Daniel Vestma Norén, Emely Overby, Kimmie Schäfferling Britoft, Mads Jens Køie Nielsen, Mette Michelle Unterborg Alempiew and Michelle Vigant Nielsen

"How can a mathematical model aid in curing leukaemia?"

2018

Mathis Brette Mortensen, Natalia Stati, Irida Gkouzou and Magnus Skjold Frederiksen

"Parameters estimation in a Myeloproliferative Neoplasm model"

2017

Jeannie Bøg Rasmussen, Maria Nørr and Mehmet Temizsoy

"Quasi-SteadyState assumption on a Mathematical Model of Leukemia"

2017

Mikkel Zielinski Ajslev, Hasan M. M. Osman and Stefan Bisgaard

The Cancitis Model

Our main work concerns the Cancitis Model, as introduced in our 2017 PLOS One paper. Below is a schematic overview of the compartments of the model.

The corresponding system of ordinary differential equations is given as:

$$ \begin{align} \frac{dx_0}{dt} &= (r_x \phi_x s- a_x - d_{x0}) x_0 - r_m s x_0 \\ \frac{dx_1}{dt} &= a_x A_x x_0 - d_{x1} x_1 \\ \frac{dy_0}{dt} &= (r_y \phi_y - a_y - d_{y0}) y_0 + r_m s x_0 \\ \frac{dy_1}{dt} &= a_y A_y y_0 - d_{y1} y_1 \\ \frac{da}{dt} &= d_{x0} x_0 + d_{y0} y_0 + d_{x1} x_1 + d_{y1} y_1 -e_a a s\\ \frac{ds}{dt} &= r_s a - e_s s + I \end{align} $$
where \( \phi_x (x_0,y_0) = \frac{1}{1+c_{xx}x_0 + c_{xy}y_0} \) and \( \phi_y (x_0,y_0) = \frac{1}{1+c_{yx}x_0 + c_{yy}y_0} \)

In our 2019 JTB paper (Ottesen et al, 2019), we showed that a model reduction is possible. More information and additional figures can be found here.